Hot Logistics Companies To Invest In Right Now

Lockheed Martin (NYSE: LMT  ) �landed a pair of Pentagon contracts Thursday, worth some $85 million in aggregate.

The smaller of the two awards, for $14.6 million, went to a small Lockheed unit called Lockheed Martin Gyrocam Systems LLC. Gyrocam won a task order to provide field service representatives to assist the Navy on a vehicle optic surveillance system program in Afghanistan, including providing parts, logistics, maintenance, and training support for legacy systems. Lockheed's work on this contract should be complete by July 2014.

The larger award, this one for a more substantial $70.4 million, modifies a previously awarded advance acquisition contract to provide Lockheed with the funds needed to buy "long lead-time" parts, material, and components that will be required to build seven Conventional Take-Off and Landing F-35A Lightning II Joint Strike Fighter aircraft, and one Short Take-Off Vertical Landing F-35B Lightning II Joint Strike Fighter aircraft. All eight aircraft are destined for the Italian Air Force. Work on this long-lead contract is to be completed by February 2014.�

Hot High Dividend Companies To Buy Right Now: Granite Broadcasting Corp (GRRP)

Granite Broadcasting Corporation (Granite), incorporated in 1988, is a television broadcasting company focused on developing and operating small- to middle-market television broadcast stations in the United States. The Company owns and operates six middle-market stations, and has shared services agreements and advertising representation agreements to two additional stations owned by Malara Broadcast Group and one additional station owned by Four Seasons Broadcast Company. Granite's revenues are derived principally from local and national advertising and, to a lesser extent, from network compensation for the broadcast of programming, and from studio rental and commercial production activities. On July 26, 2006, the Company completed the acquisition of WBNG, Channel 12, the CBS-affiliated television station serving Binghamton and Elmira, New York. In December 2006, Granite, along with certain of its subsidiaries, voluntarily filed petitions for reorganization under Chapter 11 of the United States Bankruptcy Code in the United States Bankruptcy Court for the Southern District of New York.

The stations that Granite owns and the stations to which the Company provides services under local services agreements operate in geographically diverse markets. With respect to the stations the Company owns, as of December 31, 2005, two stations are located in the west region (KBWB-San Francisco, California and KSEE-Fresno, California); four stations are located in the mid-west region (WDWB- Detroit, Michigan; WEEK-Peoria, Illinois; WISE-Fort Wayne, Indiana, and KBJR-Duluth, Minnesota), and two stations are located in the northeast region (WKBW-Buffalo and WTVH-Syracuse, New York).

As of December 31, 2005, four of the eight stations the Company owns are affiliated with NBC, one is affiliated with ABC, one is affiliated with CBS and two are affiliated with the WB Network, which has announced that it will no longer provide programming to WB affiliates effective September 2006. All three of the s! tations to which the Company provides services under local services agreements are located in the midwest region (WPTA-Fort Wayne, Indiana; KDLH-Duluth, Minnesota, and WAOE- Peoria, Illinois). WPTA is affiliated with ABC, KDLH is affiliated with CBS and WAOE is affiliated with UPN.

Affiliates of the major networks, which include NBC, ABC, CBS and Fox, receive a significant portion of their programming each day from the network. These major networks provide programming, and in some cases, cash payments, to their affiliated stations in exchange for a significant portion of the affiliates' advertising inventory during the network provided programs. These networks then sell this advertising time and retain the revenue.

Granite has entered into affiliation agreements with networks for each of the stations the Company owns. KSEE, WEEK, WISE (acquired on March 8, 2005) and KBJR are affiliated with NBC, WKBW is affiliated with ABC, WTVH is affiliated with CBS, and KBWB and WDWB stations are affiliated with WB. WPTA, which Granite sold, on March 7, 2005, to Malara Broadcast Group, is affiliated with ABC. With respect to the two stations that are owned by Malara Broadcast Group to which, since March 8, 2005, the Company provides services under local services agreements, KDLH is affiliated with CBS and WPTA is affiliated with ABC. WAOE, which is owned by Four Seasons Broadcast Company, is affiliated with UPN. In addition to these network affiliation agreements, Granite delivers WB programming on leased cable channels in Fort Wayne, Indiana and Duluth, Minnesota-Superior, Wisconsin. In the Duluth, Minnesota-Superior, Wisconsin, the Company delivers UPN programming on one of KBJR's digital streams, which programming is retransmitted in analog format by certain major cable systems in the DMA. In addition, KRII multicasts Weather Plus on another of KBJR's digital streams.

Since March 8, 2005, Granite has shared services agreements and advertising representation agreements (or loc! al servic! e agreements) to provide advertising, sales promotion and administrative services, and selected programming to two additional stations owned by Malara Broadcast Group, all of which Granite and Malara stations are affiliated with either ABC, NBC or CBS, the Company's Big Three Affiliates. On September 8, 2005, Granite entered into a definitive agreement (the KBWB Purchase and Sale Agreement) to sell substantially all of the assets of KBWB-TV, the WB affiliate serving the San Francisco, California television market, to AM Broadcasting KBWB, Inc. (the KBWB Buyer). In addition, on September 8, 2005, the Company entered into a definitive agreement (the WDWB Purchase and Sale Agreement, and together with the KBWB Purchase and Sale Agreement, the Purchase and Sale Agreements) to sell substantially all of the assets of WDWB-TV, the WB affiliate serving the Detroit Michigan television market, to AM Broadcasting WDWB, Inc. (the WDWB Buyer).

On September 1, 2005, Granite entered into an arrangement with Four Seasons Broadcast Company, under which the Company will provide advertising, sales promotion and administrative services to Four Seasons Broadcast Company-owned station WAOE-TV, the UPN affiliate serving Peoria-Bloomington, Illinois, in return for certain fees that will be paid by Four Seasons Broadcast Company to Granite. On January 13, 2006, Granite and certain of its subsidiaries entered into a definitive agreement with Television Station Group Holdings, LLC and certain of its subsidiaries to purchase substantially all of the assets of WBNG-TV, Channel 12, the CBS-affiliated television station serving Binghamton and Elmira, New York.

Advisors' Opinion:

• [By Lauren Pollock]

  E.W. Scripps Co.(SSP) agreed to acquire two television stations, one in Detroit and another in Buffalo, N.Y., for a combined $110 million from Granite Broadcasting Corp.(GRRP)

Hot Logistics Companies To Invest In Right Now: Maiden Hldgs Ltd(MHLD)

Maiden Holdings, Ltd., through its subsidiaries, provides reinsurance solutions to regional and specialty insurers primarily in the United States and Europe. The company offers property, casualty, accident, and health reinsurance products. It offers its products through the treaties with other insurers on a quota share or excess of loss basis, as well as on a facultative basis through third-party intermediaries and on direct basis. Maiden Holdings, Ltd. was founded in 2007 and is headquartered Hamilton, Bermuda.

Advisors' Opinion:

• [By Marc Bastow]

  Bermuda-based reinsurance solutions provider Maiden Holdings (MHLD) raised its quarterly dividend 22% to 11 cents per share, payable on Jan. 15 to shareholders of record as of Jan. 2.
  MHLD Dividend Yield: 3.79%
  

Hot Logistics Companies To Invest In Right Now: Arlington Asset Investment Corp (AI)

Arlington Asset Investment Corp. is a principal investment firm that acquires mortgage-related and other assets. The Company acquires residential mortgage-backed securities (MBS), either issued by United States government agencies or guaranteed as to principal and interest by United States government agencies or United States government-sponsored entities (agency-backed MBS). It also acquires MBS issued by private organizations (private-label MBS). It manages a portfolio of mortgage holdings with the goal of obtaining a high risk-adjusted return on capital. The Company acquires direct interests in residential MBS guaranteed as to principal and interest by Fannie Mae or Freddie Mac.

The Company focuses on acquiring Fannie Mae MBS and Freddie Mac MBS. It also acquires and holds non-agency private-label MBS. Private-label MBS are MBS that are not issued by the United States Government agency or a United States Government-sponsored entity, such as Fannie Mae or Freddie Mac, and that are generally backed by a pool of single-family residential mortgage loans. Certificates are issued by originators of, investors in, and other owners of residential mortgage loans, including savings and loan associations, savings banks, commercial banks, mortgage banks, investment banks and special purpose conduit subsidiaries of these institutions. The Company focuses on acquiring Residential Prime Senior MBS, Residential Non-Prime Senior MBS, Residential Subordinate MBS and Residential Re-REMIC Support MBS.

Advisors' Opinion:

• [By Alyssa Oursler]

  Arlington Asset Investment Corp. (AI) is an investment firm that acquires mortgage-related and other assets — and that rewards investors with a juicy dividend.

• [By Ning Jia]

  Reuters Description: Advance Auto Parts, Inc. (Advance), incorporated on August 1, 2001, is a specialty retailer of automotive aftermarket parts, accessories, batteries and maintenance items primarily operating within the United States. The Company operates in two segments: Advance Auto Parts (AAP), and Autopart International (AI). The AAP segment is comprised of its store operations, which operate under the trade names Advance Auto Parts and Advance Discount Auto Parts.The AI segment consists of the operations of Autopart International, Inc. which operates under the Autopart International trade name. The Company�� stores carry a product line for cars, vans, sport utility vehicles and light trucks.The Company serves both do-it-yourself (DIY), and do-it-for-me (Commercial), customers. Its Commercial customers consist primarily of delivery customers for whom the Company delivers product from its store locations to it Commercial customers��places of business, including independent garages, service stations and auto dealers. On December 31, 2012, the Company acquired B.W.P. Distributors, Inc.
  

• [By victorselva]

  The Charles Schwab Corporation (SCHW) is a savings and loan holding company. The company is engaged, through its subsidiaries, in securities brokerage, banking, money management, and financial advisory services. Its subsidiaries include Charles Schwab & Co. (a leading discount broker-dealer), Charles Schwab Investment Management (a mutual fund investment advisor) and Charles Schwab Bank.In this article, let's take a look at this brokerage firm and try to explain to investors the reasons this is an apparently appealing investment opportunity.The FocusThe company provides financial services to individuals and institutional clients through two segments: Investor Services and Institutional Services. The Investor Services segment provides retail brokerage and banking services to individual investors. The Institutional Services segment provides custodial, trading, and support services to independent investment advisors. The Institutional Services segment also provides retirement plan services, specialty brokerage services, and mutual fund clearing services. The company seeks to meet the financial services needs of investors, advisers and employers. It focuses on building client loyalty with the goal of attracting new clients and serving them. Additionally, Schwab麓s strengths through shared core processes and technology advances which help create services that are scalable and consistent with the business.Interest Rates, Capital Structure and Debt-to-Capital RatioThe results are dependent on short-term interest rates, as 37% of its top line came from net interest income in the first quarter of 2014.The broker has been making significant efforts to become less dependent on interest rates, which we expect Federal Reserve will raise them in late 2014 or 2015. Also, the company麓s plan is to reach a low-cost capital structure and targets a long-term debt-to-total financial capital ratio of less than 30%.Lucrative Derivatives Trading In 2011, the company acquired Compl

• [By Eric Volkman]

  Arlington Asset Investment (NYSE: AI  ) continues to distribute some of its take in the form of shareholder payouts. The company has declared a dividend for its Q2 of $0.875 per share. This will be paid on July 31 to shareholders of record as of June 28. That amount matches each of the firm's preceding quarterly distributions stretching back to mid-2011. Prior to that, it handed out $0.75 per share.

Hot Logistics Companies To Invest In Right Now: Emergent Biosolutions Inc. (EBS)

Emergent BioSolutions, Inc., a specialty pharmaceutical company, engages in the development, manufacture, and commercialization of specialized products for use in defense and commercial markets in the United States and internationally. The company operates in two segments, Biodefense and Biosciences. It markets BioThrax, an FDA licensed vaccine for the prevention of anthrax disease; and RSDL (decontamination lotion) product for removal or neutralization of chemical warfare agents from the skin. The company�s development pipeline includes Anthrivig (Human Anthrax Immunoglobulin), a polyclonal anthrax therapeutic candidate; PreviThrax, a recombinant anthrax vaccine candidate, NuThrax (Anthrax Vaccine Adsorbed with CPG 7909 Adjuvant); BioThrax with a novel adjuvant; and Thravixa (Fully Human Anthrax Monoclonal Antibody), a therapeutic being studied for use against symptomatic anthrax infection. In addition, it develops TRU-016, a humanized anti-CD37 therapeutic candidate, ba sed on its ADAPTIR (Modular Protein Technology) platform that is in Phase I/II clinical trials to treat chronic lymphocytic leukemia. Further, the company develops preclinical product candidates targeted for solid tumors, inflammatory bowel disease, graft versus host disease, rheumatoid arthritis, and a human vaccine to protect against influenza caused by a range of circulating H5 influenza strains. Emergent BioSolutions, Inc. was founded in 1998 and is headquartered in Rockville, Maryland.

Advisors' Opinion:

• [By Traders Reserve]

  I discovered Emergent Bio Solutions (EBS) when I ran my proprietary P/E Gap model at the end of December. Without getting into the details, P/E Gap identifies stocks that have the potential to rally based on being significantly undervalued.

• [By Stephen Quickel]

  Emergent BioSolutions (EBS) is a far smaller specialist in bio-medical products for the military and commercial markets, including anthrax vaccine and decontamination agents. With revenues nearing $400 million, EBS is acquiring Canada's Cangene Corp. to expand its product line.

Hot Logistics Companies To Invest In Right Now: Actuant Corp (ATU)

Actuant Corporation, incorporated on October 26, 1910, is a global diversified company that designs, manufactures and distributes a range of industrial products and systems to various end markets. The Company operates four business segments: Industrial, Energy, Electrical and Engineered Solutions. The Industrial segment is primarily involved in the design, manufacture and distribution of branded hydraulic and mechanical tools to the maintenance, industrial, infrastructure and production automation markets. The Energy segment provides joint integrity products and services, as well as rope and cable solutions to the global oil and gas, power generation and other energy markets. The Electrical segment is primarily involved in the design, manufacture and distribution of a range of electrical products to the retail DIY, wholesale, original equipment manufacturer (OEM), solar, utility, marine and other harsh environment markets. The Engineered Solutions segment provides engineered position and motion control systems to OEMs in various on and off-highway vehicle markets, as well as, a range of other products to the industrial and agricultural markets. In August 2013, the Company announced the completion of its acquisition of Viking SeaTech (Viking).

Industrial

The Industrial segment is a global supplier of branded hydraulic and mechanical tools to a broad array of end markets, including general maintenance and repair, industrial, infrastructure and production automation. The Company's primary products include hydraulic tools, engineered heavy lifting solutions, workholding (production automation) solutions and concrete stressing products. These hydraulic and mechanical tools are marketed primarily through the Company's Enerpac, Simplex, Precision Sure-Lock and Milwaukee Cylinder brand names. The high-force hydraulic and mechanical tools, including cylinders, pumps, valves, specialty tools and presses.

The Company's hydraulic tools operate at high pressures of approxim! ately 5,000 to 12,000 pounds per square inch and are generally sold by a diverse group of industrial and specialty fluid power distributors to customers in the infrastructure, mining, steel mill, cement, rail, oil and gas and general maintenance industries. Key industrial distributors include W.W. Grainger, Applied Industrial Technologies and MSC. In addition to providing a line of industrial tools, the segment also provides hydraulic systems (integrated solutions) to meet customer specific requirements for safe and precise control of movement and positioning. These customized heavy lifting solutions, which combine hydraulics, steel fabrication and electronic controls with engineering and application knowledge, are typically utilized in major infrastructure projects (bridges, stadiums, tunnels and offshore platforms) for heavy lifting, launching & skidding or synchronous lifting applications.

The Industrial segment has leveraged production and engineering capabilities to also offer a range of workholding products (work supports, swing cylinders and system components) that are marketed through distributors to the automotive, machine tool and fixture design markets. In addition, the segment designs, manufactures and distributes concrete pre- and post-tensioning products (chucks and wedges, stressing jacks and anchors) which are used by concrete tensioning system designers, fabricators and installers for the residential and commercial construction, railroad, bridge, infrastructure and mining markets.

Energy

The Energy segment provides technical products and services to the global energy markets, where safety, security, reliability and productivity are key value drivers. Products include joint integrity tools and connectors for oil & gas and power generation installations, as well as rope and cable solutions. In addition to these products, the Energy segment also provides manpower services, including machining, engineering and maintenance activities. The products and ! services ! of the Energy segment are distributed and marketed under various brand names (principally Hydratight, D.L. Ricci, Morgrip, Cortland, FibronBX, Puget Sound Rope, Biach, Selantic and Jeyco) to OEMs, maintenance and service organizations and energy producers in emerging and developed countries.

Joint integrity products include hydraulic torque wrenches, bolt tensioners and portable machining equipment. These products are used in the maintenance of bolted joints on oil rigs and platforms, wind turbines, refineries and pipelines, petrochemical installations, as well as fossil fuel and nuclear power plants. The Energy segment also provides rope and cable solutions that maximize performance, safety and efficiency for customers in various markets, including oil and gas, heavy marine, subsea, ROV and seismic. With its global design and manufacturing capabilities the Cortland business is able to provide customized synthetic ropes, heavy lift slings, specialized mooring, rigging and towing systems, electro-optical-mechanical cables and umbilicals to customers, including firms, such as CGG Veritas, Expro and Sercel. These products are utilized in critical applications, often deployed in harsh operating conditions (sub-sea oil & gas production, maintenance and exploration) and are required to meet robust safety standards. In addition custom designed products are also sold into a range of other niche markets including medical, security, aerospace and defense.

Electrical

The Electrical segment is involved in the design, manufacture and distribution of a broad range of electrical products to the retail DIY, OEM, electrical distribution, power transformation and harsh environment electrical markets. The Electrical segment sells its products through a combination of distributors, direct sales personnel and manufacturers' representatives. The Electrical segment provides the retail DIY market with a range of electrical tools and consumables, such as wire strippers, electrical meters,! connecto! rs, terminals, cable ties, staples and other wire management products and conduit bending equipment under the Gardner Bender, Del City and A.W. Sperry brands. These products are sold to retailers, such as Lowe's, The Home Depot, Menards, True Value and Ace Hardware, as well as numerous electrical distributors and OEM's.

The Electrical segment sells power transformation products in North America, including low voltage, single-phase dry type transformers and custom toroidal transformers under the Acme Electric brand name and high voltage switches under the Turner Electric brand name. These transformers are sold through electrical wholesale distributors, as well as directly to OEMs, such as Rockwell Automation, Eaton, Yaskawa and General Electric. Product offerings also include electrical components and systems for the harsh environment and marine markets under the Ancor, Marinco, Guest, Mastervolt and B.E.P Marine brand names. These products are primarily sold to various customers in the industrial, marine, power generation, industrial and retail markets, including West Marine, Applied Materials and Kohler. Solar products (primarily high efficiency solar inverters for residential and small commercial applications) are sold through local distributors and installers.

Engineered Solutions

The Engineered Solutions segment is a global designer and assembler of customized position and motion control systems and other industrial products to various transportation and other niche markets. This segment focuses on providing technical and engineered products, including actuation systems, mechanical power transmission products, engine air flow management solutions and rugged electronic instrumentation. Products in the Engineered Solutions segment are primarily marketed directly to OEMs through a technical sales organization. Approximately 55% of this segment's revenue comes from the vehicle systems product line (Power-Packer, Gits and Power Gear brands), which is sold to the t! ruck, aut! omotive, off-highway and specialty vehicle markets. Products include hydraulic cab-tilt and latching systems, which are sold to global heavy duty truck OEMs, such as Volvo, Iveco, Scania, Paccar-DAF and CNHTC and electro-hydraulic convertible top latching and actuation systems. The automotive convertible top actuation systems are utilized on both retractable soft and hard top vehicles manufactured by OEMs, such as Daimler, Volkswagen, Renault, Peugeot, BMW, Volvo and Nissan.

The Company's diesel engine air flow solutions, such as exhaust gas recirculation (EGR) systems, are used by diesel engine and turbocharger manufacturers to reduce emissions, improve fuel efficiency and horsepower. Primary end markets include heavy duty truck and off-highway equipment serving customers, such as Caterpillar, Cummins, Honeywell and Borg Warner. It also sells actuation systems to various specialty vehicle OEMs (principally in the defense, recreational vehicle and off-highway markets), such as Oshkosh and Fleetwood.

The Maxima Technologies tuck-in acquisitions of Turotest Medidores Ltda and CrossControl AB, along with the fiscal 2011 acquisition of Weasler Engineering have further diversified the geographic presence, technologies and end markets of the Engineered Solutions segment. The range of products, technologies and engineered solutions of Weasler Engineering, Maxima Technologies, Elliott Manufacturing, Sanlo and Nielsen Sessions comprise the other product line within the segment. Products include severe-duty electronic instrumentation (including displays and clusters, machine controls and sensors), power transmission products (engineered power transmission components, including drive shafts, torque limiters, gearboxes, torsional dampers and flexible shafts), and a comprehensive line of case, container and industrial hardware. These products are sold to a range of niche markets, including agricultural implement, lawn & turf, construction, forestry, industrial, aerospace, material handling! and secu! rity.

Advisors' Opinion:

• [By Monica Gerson]

  Analysts expect Actuant (NYSE: ATU) to report its Q3 earnings at $0.63 per share on revenue of $376.57 million. Actuant shares gained 0.83% to close at $36.30 yesterday.

• [By Monica Gerson]

  Analysts expect Actuant (NYSE: ATU) to report its Q4 earnings at $0.50 per share on revenue of $328.79 million. Actuant shares fell 0.21% to $38.76 in after-hours trading.

• [By Seth Jayson]

  When judging a company's prospects, how quickly it turns cash outflows into cash inflows can be just as important as how much profit it's booking in the accounting fantasy world we call "earnings." This is one of the first metrics I check when I'm hunting for the market's best stocks. Today, we'll see how it applies to Actuant (NYSE: ATU  ) .

Hot Logistics Companies To Invest In Right Now: Airgas Inc.(ARG)

Airgas, Inc., through its subsidiaries, distributes industrial, medical, and specialty gases, as well as hardgoods in the United States. The company offers various gases, including nitrogen, oxygen, argon, helium, and hydrogen; welding and fuel gases, such as acetylene, propylene, and propane; and carbon dioxide, nitrous oxide, ultra high purity grades, special application blends, and process chemicals. Its hardgoods products comprise welding consumables and equipment, safety products, and construction supplies, as well as maintenance, repair, and operating supplies. The company also engages in the rental of gas cylinders, cryogenic liquid containers, bulk storage tanks, tube trailers, and welding and welding related equipment. In addition, the company manufactures and distributes liquid carbon dioxide, dry ice, nitrous oxide, ammonia, refrigerant gases, and atmospheric merchant gases. It serves repair and maintenance, industrial manufacturing, energy and infrastructure co nstruction, medical, petrochemical, food and beverage, retail and wholesale, analytical, utilities, and transportation industries. The company operates an integrated network of approximately 1100 locations, including branches, retail stores, packaged gas fill plants, specialty gas labs, production facilities, and distribution centers. Additionally, it provides retail solutions to retail customers, such as florists, grocers, restaurants and bars, tire and automotive service centers, and others. The company markets its products through multiple sales channels, including branch-based sales representatives, retail stores, strategic customer account programs, telesales, catalogs, e-business, and independent distributors. Airgas, Inc. was founded in 1982 and is based in Radnor, Pennsylvania.

Advisors' Opinion:

• [By Monica Gerson]

  Airgas (NYSE: ARG) is expected to report its Q2 earnings at $1.22 per share on revenue of $1.28 billion.

  The Boeing Company (NYSE: BA) is estimated to report its Q3 earnings at $1.55 per share on revenue of $21.68 billion.

• [By Ben Levisohn]

  The one problem: Air Products & Chemicals valuation. “[Air Products & Chemicals] has generally been at a discount to [Praxair] in the last five years due to its mix and more volatile performance, but closed the gap last year on activist involvement and potential restructuring,” Yang and Amadeo note.�Air Products & Chemicals trades at 21 times 2015 earnings, in line with Airgas’s (ARG) P/E ratio of 21.5 but well above Praxair’s 18.5 times.

Hot Logistics Companies To Invest In Right Now: Puma Biotechnology Inc (PBYI)

Puma Biotechnology, Inc., incorporated in April 2007, is a development-stage biopharmaceutical company that acquires and develops products for the treatment of various forms of cancer. The Company focuses on in-licensing drug candidates that are undergoing or have already completed initial clinical testing for the treatment of cancer and then seeks to further develop those drug candidates for commercial use. As of December 31, 2011, the Company licensed three drug candidates: PB272 (neratinib (oral)), which the Company is developing for the treatment of advanced breasts cancer patients and gastric cancer patients; PB272 (neratinib (intravenous)), which the Company is developing for the treatment of advanced cancer patients, and PB357.

PB272 (neratinib (oral))-Breast Cancer

Neratinib is a potent irreversible tyrosine kinase inhibitor, or TKI, that blocks signal transduction through the epidermal growth factor receptors (EGFRs), HER1, HER2 and HER4. The Company's initial focus is on the development of neratinib as an oral treatment of patients with HER2 positive metastatic breast cancer.

PB272 (neratinib (intravenous))

The Company develops neratinib as an intravenously administered agent. In pre-clinical studies the intravenous version of neratinib resulted in higher exposure levels of neratinib in pre-clinical models.

PB357

PB357 is an orally administered agent that is an irreversible TKI that blocks signal transduction through the epidermal growth factor receptors, HER1, HER2, and HER4. PB357 is structurally similar to PB272. Pfizer completed single dose Phase I trials of PB357. The Company is evaluating PB357.

The Company competes with Genentech, GlaxoSmithKline, Roche, Boehringer Ingelheim, Takeda, Array Biopharma and Ambit Biosciences.

Advisors' Opinion:

• [By Ben Levisohn]

  The Dow Jones Industrial Average and S&P 500 squeaked out new highs today, while the Nasdaq Composite and small caps dropped, following stronger-than-forecast manufacturing data out of China and a U.S. manufacturing survey that had to be corrected twice. Caterpillar (CAT) and Broadcom�(BRCM) gained, while Express Scripts (ESRX) and Puma Biotechnology (PBYI) tumbled.

• [By John Udovich]

  Recent news surrounding small cap biotech stocks like�Xencor Inc (NASDAQ: XNCR), Prosensa Holding NV (NASDAQ: RNA),�Puma Biotechnology Inc (NYSE: PBYI),�Geron Corporation (NASDAQ: GERN)
  and TNI BioTech Inc (OTCQB: TNIB) show that while the sector and appetite for biotech�IPOs may have cooled, lottery tickets can still be found or occur in the sector. Just consider the following recent news or trends:

• [By John Udovich]

  Yesterday, small cap biopharmaceutical stock Puma Biotechnology Inc (NYSE: PBYI) jumped 11.98% after announcing they will have a conference call next week to update�investors on�its clinical trials of PB272 (neratinib) in cancer patients, meaning its probably time to take a closer look at the stock to see if investor might be counting the chickens before they hatch along with the performance of large cap AbbVie Inc (NYSE: ABBV) which also recently had positive news about its own breast cancer treatment plus biotech ETFs iShares NASDAQ Biotechnology Index ETF (NASDAQ: IBB) and SPDR S&P Biotech ETF (NYSEARCA: XBI).

• [By Anna Prior]

  Puma Biotechnology Inc.(PBYI) reported positive top-line data from the Phase II clinical trial of the biopharmaceutical company’s investigational drug PB272 for the neoadjuvant treatment of breast cancer.